R&D

Xenotransplantation

Research Achievements

Optipharm's Xenotransplantation Business

Key Points in History

  • 2007

    2007

    MiniPig imorted

    Business start

  • 2013

    2013

    Somatic Cell
    Cloning Technology

    through Fluorescent
    pig production

  • 2015

    2015

    Using Genetic Scissors

    for GT Homo Pig production

  • 2020

    2021

    Securing the world's highest level of islet isolation yield

    Islet cells from a pig can be transplanted into a human

Current status of research

  • Current status of research

Research process and Status

Raw material
animals		 Transformation Preclinic (primate) Clinic (human body) Conditional
approval		 Commercialization
Status of securing raw material animals
Status of securing transgenic pigs
Clinical Research Results on Primates
Planned clinical trials in primate islet xenotransplantation

Major Achievements

  • Triple Knock-out
    Securing transgenic mini pigs

    Transgenic Research, 2021

  • Securing the world's highest level
    efficiency in islet isolation

    Xenotransplantation, 2021

Environmental
Change

  • Guidelines for Quality, Non-Clinical, and Clinical Evaluation of Heterogeneous Transplants

    (22.10.31, Ministry of Food and Drug Safety)
  • Successful xenotransplantation of the heart and kidney (Jan. 2022, U.S.)Go Link
  • Act on the Safety of and Support for Advanced Regenerative Medicine and Advanced
    Biological Products (Abbreviated as: Advanced Regenerative Bio Act)
    [Enforced: Sep. 12, 2020]
  • Genetically engineered pigs approved for food use by the US FDA